Basic information
Biomarker: KAI
Biomarker subtype: gene
Clinical application: prognosis(unfavorable)
Histology type: endometrial carcinoma
Stage: advanced stage
Cohort characteristics
Country: Republic of China
Region: Taiwan
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 189 | EC | 143 | endometrial hyperplasia | 18 | metastatic lesions | 28 |
Sample information
Sample type : tissue
Clinical method: real-time quantitative PCR /immunohistochemical
Expression pattern : down-regulated
Disease information
Related information
Description: These data suggest that KAI1 expression is down-regulated in advanced endometrial cancer. Clinically it may be a useful indicator of the tumor progression and may provide prognostic information on the outcome of this disease.
Approved symbol: CD82
Approved name: CD82 molecule
Locus type: gene with protein product
HGNC ID: HGNC:6210
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6210
Symbol status: Approved
Previous symbols: ST6 KAI1
Alias symbols: R2 IA4 TSPAN27
Alternative gene group name: Tetraspans, Transmembrane 4 superfamily, TM4SF |cluster of differentiation molecules", "cluster of designation molecules
OMIM: 600623
Omim link: https://www.omim.org/entry/602969
NCBI name: 3732
NCBI link: https://www.ncbi.nlm.nih.gov/gene/3732
Summary: This metastasis suppressor gene product is a membrane glycoprotein that is a member of the transmembrane 4 superfamily. Expression of this gene has been shown to be downregulated in tumor progression of human cancers and can be activated by p53 through a consensus binding sequence in the promoter. Its expression and that of p53 are strongly correlated, and the loss of expression of these two proteins is associated with poor survival for prostate cancer patients. Two alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jul 2008]
Expression: Ubiquitous expression in esophagus (RPKM 44.7), bone marrow (RPKM 32.0) and 25 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/3732#gene-expression
PDB ID: P27701
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P27701)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
