Biomarker: CK-20

Biomarker subtype: mRNA

Clinical application: diagnosis

Histology type: endometrial carcinoma

Country: Israel

Region: Kfar Saba

Sample type : tissue

Clinical method: RT-PCR

Expression pattern : positive expression

Expression elevation: Appearance of 370-bp band presented positive CK-20 results;

Description: These results indicate that RT-PCR of CK-20, because of its high sensitivity, is a potential biomarker for detecting endometrial carcinoma.

Approved symbol: KRT20

Approved name: keratin 20

Locus type: gene with protein product

HGNC ID: HGNC:20412

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:20412

Symbol status: Approved

Previous symbols: keratin 20, type I

Alias symbols: CK20 K20 MGC35423

Alternative gene group name: Keratins (acidic)", "Acidic keratins", "Type I keratins", "Type I intermediate filaments", "Type I cytokeratins"

Subgroup: Keratins (KRT)

OMIM: 608218

Omim link: https://www.omim.org/entry/608218

NCBI name: 54474

NCBI link: https://www.ncbi.nlm.nih.gov/gene/54474

Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. This cytokeratin is a major cellular protein of mature enterocytes and goblet cells and is specifically expressed in the gastric and intestinal mucosa. The type I cytokeratin genes are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]

Expression: Biased expression in small intestine (RPKM 435.8), colon (RPKM 405.3) and 3 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/54474#gene-expression

PDB ID: P35900

PDB link: https://alphafold.ebi.ac.uk/entry/P35900