Biomarker: p53

Biomarker subtype: gene

Clinical application: prognosis(unfavorable)

Histology type: endometrioid endometrial carcinoma

Country: Japan

Region: Sendai

Study type: retrospective study

Sample type : tissue

Clinical method: PCR-SSCP

Expression pattern : abnormalities

Expression elevation: Immunostained slides were evaluated according to both the intensity of staining and the number of positive tumour cells as follows:3 tumours were classified as strongly positive when nuclear immunoreactivity was intense and/or positive cells accounted for more than 10 per cent of tumour cells; as weakly focally positive when nuclear immunoreactivity was weak and/or positive cells accounted for less than 10 per cent of tumour cells; and as negative when there was no reactivity.

Description: p53 abnormalities were considered as prognostic indicators in patients with endometrioid endometrial carcinoma.

Approved symbol: TP53

Approved name: tumor protein p53

Locus type: gene with protein product

HGNC ID: HGNC:11998

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11998

Symbol status: Approved

Alias symbols: p53 LFS1

OMIM: 191170

Omim link: https://www.omim.org/entry/191170

NCBI name: 7157

NCBI link: https://www.ncbi.nlm.nih.gov/gene/7157

Summary: This gene encodes a tumor suppressor protein containing transcriptional activation, DNA binding, and oligomerization domains. The encoded protein responds to diverse cellular stresses to regulate expression of target genes, thereby inducing cell cycle arrest, apoptosis, senescence, DNA repair, or changes in metabolism. Mutations in this gene are associated with a variety of human cancers, including hereditary cancers such as Li-Fraumeni syndrome. Alternative splicing of this gene and the use of alternate promoters result in multiple transcript variants and isoforms. Additional isoforms have also been shown to result from the use of alternate translation initiation codons from identical transcript variants (PMIDs: 12032546, 20937277). [provided by RefSeq, Dec 2016]

Expression: Ubiquitous expression in spleen (RPKM 13.2), lymph node (RPKM 13.1) and 25 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/7157#gene-expression

PDB ID: P04637

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P04637)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

BP term ID: GO:1903451$ GO:1990248$GO:1905856

BP term name: negative regulation of G1 to G0 transition$ regulation of transcription from RNA polymerase II promoter in response to DNA damage$negative regulation of pentose-phosphate shunt

Source description: REAC$WP$MIRNA

Term ID: REAC:R-HSA-9723907$REAC:R-HSA-9723905$REAC:R-HSA-6804754$REAC:R-HSA-69895$REAC:R-HSA-69560$WP:WP4284$WP:WP4399$WP:WP4191$WP:WP5043$MIRNA:hsa-miR-518c-3p$CORUM:2681$CORUM:2679$CORUM:2821$CORUM:5811$CORUM:5812$CORUM:7180$CORUM:2678$

Term name: Loss of Function of TP53 in Cancer$Loss of function of TP53 in cancer due to loss of tetramerization ability$Regulation of TP53 Expression$Transcriptional activation of cell cycle inhibitor p21$Transcriptional activation of p53 responsive genes$ Ultraconserved region 339 modulation of tumor suppressor microRNAs in cancer$MicroRNA network associated with chronic lymphocytic leukemia$Caloric restriction and aging$Pentose phosphate pathway in senescent cells$hsa-miR-518c-3p$ p53 homotetramer complex$p53-SP1 complex$hSIR2-p53 complex$ p53-BCL2 complex$p53-BCL2 complex$p53-MDM2 complex$FOXO3-TP53 complex, oxidative stress stimulated