Biomarker: VDAC2

Biomarker subtype: mRNA

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Country: Poland

Region: Lodz

Followed up time : range, 2-121months

Protocol age: 63.37±11.64

Control age: 59.55±10.17

Sample type : tissue

Clinical method: Quantitative real-time PCR

Expression pattern : expression(≥ median value)

Statictics: Mean (SD)

Protocol age: 63.37±11.64

Control age: 59.55±10.17

Description: Our results suggest that increased expression of voltage-dependent anion channels correlates with tumor progression and may serve as a potential prognostic biomarker in endometrial cancer.

Approved symbol: VDAC2

Approved name: voltage dependent anion channel 2

Locus type: gene with protein product

HGNC ID: HGNC:12672

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12672

Symbol status: Approved

Alternative gene group name: "Porins"

OMIM: 193245

Omim link: https://www.omim.org/entry/193245

NCBI name: 7417

NCBI link: https://www.ncbi.nlm.nih.gov/gene/7417

Summary: This gene encodes a member of the voltage-dependent anion channel pore-forming family of proteins that are considered the main pathway for metabolite diffusion across the mitochondrial outer membrane. The encoded protein is also thought to be involved in the mitochondrial apoptotic pathway via regulation of BCL2-antagonist/killer 1 protein activity. Pseudogenes have been identified on chromosomes 1, 2, 12 and 21, and alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2010]

Expression: Ubiquitous expression in heart (RPKM 81.3), esophagus (RPKM 66.2) and 25 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/7417#gene-expression

PDB ID: P45880

PDB link: https://alphafold.ebi.ac.uk/entry/P45880