Basic information
Biomarker: CK19
Biomarker subtype: mRNA
Clinical application: diagnosis(LN metastasis)
Histology type: endometrial carcinoma
Cohort characteristics
Country: Japanese
Region: Kagoshima
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 106 | EC | 106 |
Sample information
Sample type : tissue
Clinical method: qRT-PCR
Expression pattern : cutoff value = 4,500 copies/?L
Disease information
Related information
Description: Our results demonstrated that qRT-PCR assay, using CK19 mRNA, exhibits a high accuracy for detecting LN metastasis in EC and represents a useful alternative to conventional pathological diagnosis of EC.
Approved symbol: KRT19
Approved name: keratin 19
Locus type: gene with protein product
HGNC ID: HGNC:6436
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6436
Symbol status: Approved
Previous symbols: keratin 19, type I
Alias symbols: K19 CK19 K1CS MGC15366
Alternative gene group name: "Keratins (acidic)", "Acidic keratins", "Type I keratins", "Type I intermediate filaments", "Type I cytokeratins"
Subgroup: Keratins (KRT)
OMIM: 148020
Omim link: https://www.omim.org/entry/148020
NCBI name: 3880
NCBI link: https://www.ncbi.nlm.nih.gov/gene/3880
Summary: The protein encoded by this gene is a member of the keratin family. The keratins are intermediate filament proteins responsible for the structural integrity of epithelial cells and are subdivided into cytokeratins and hair keratins. The type I cytokeratins consist of acidic proteins which are arranged in pairs of heterotypic keratin chains. Unlike its related family members, this smallest known acidic cytokeratin is not paired with a basic cytokeratin in epithelial cells. It is specifically expressed in the periderm, the transiently superficial layer that envelopes the developing epidermis. The type I cytokeratins are clustered in a region of chromosome 17q12-q21. [provided by RefSeq, Jul 2008]
Expression: Biased expression in colon (RPKM 351.9), stomach (RPKM 332.4) and 13 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/3880#gene-expression
PDB ID: P08727
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index?uniprot_accession:(P08727)
CC term ID: GO:1990357
CC term name: terminal web
