Biomarker: TRPV2

Biomarker subtype: mRNA

Clinical application: diagnosis

Histology type: endometrial carcinoma

Stage: high risk

Country: Belgium

Region: UZ Gasthuisberg

Followed up time : 36 months,median

Sample type : tissue

Clinical method: RT-qPCR/intracellular Ca2+ imaging

Expression pattern : expression

Validation in cell line : primary endometrial cancer cell cultures (EM018a, EM033, EM012 and EM046)

Validation in cell method : RT-qPCR,Calcium microfluorimetry,immunohistochemistry,western blot (WB)

Description: Altogether, these data suggest TRPV2 gene expression in the primary tumor biopsy as a valuable predictor for disease recurrence.

Approved symbol: TRPV2

Approved name: transient receptor potential cation channel subfamily V member 2

Locus type: gene with protein product

HGNC ID: HGNC:18082

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18082

Symbol status: Approved

Previous symbols: transient receptor potential cation channel, subfamily V, member 2

Alias symbols: VRL VRL-1 VRL1

Alternative gene group name: $ANK repeat containing

Subgroup: Voltage-gated ion channels

OMIM: 606676

Omim link: https://www.omim.org/entry/606676

NCBI name: 51393

NCBI link: https://www.ncbi.nlm.nih.gov/gene/51393

Summary: This gene encodes an ion channel that is activated by high temperatures above 52 degrees Celsius. The protein may be involved in transduction of high-temperature heat responses in sensory ganglia. It is thought that in other tissues the channel may be activated by stimuli other than heat. [provided by RefSeq, Jul 2008]

Expression: Broad expression in lung (RPKM 13.6), spleen (RPKM 9.9) and 23 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/51393#gene-expression

PDB ID: Q9Y5S1

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index?uniprot_accession:(Q9Y5S1)

Source description: MIRNA

Term ID: MIRNA:hsa-miR-3186-3p

Term name: hsa-miR-3186-3p