Biomarker: Autotaxin

Biomarker subtype: gene

Clinical application: treatment(theranostic target)

Histology type: endometrioid endometrial carcinoma

Country: Italy

Region: Bari

Study type: prospective

Sample type : tissue

Clinical method: Quantitative real time PCR

Expression pattern : expression

Description: ATX as a novel potential biomarker particularly implicated in the pathobiology of type I endometrial cancer. Also, we propose ATX as a useful theranostic target in endometrial cancer.

Approved symbol: ENPP2

Approved name: ectonucleotide pyrophosphatase/phosphodiesterase 2

Locus type: gene with protein product

HGNC ID: HGNC:3357

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3357

Symbol status: Approved

Previous symbols: PDNP2

Alias symbols: ATX PD-IALPHA

OMIM: 601060

Omim link: https://www.omim.org/entry/601060

NCBI name: 5168

NCBI link: https://www.ncbi.nlm.nih.gov/gene/5168

Summary: The protein encoded by this gene functions as both a phosphodiesterase, which cleaves phosphodiester bonds at the 5' end of oligonucleotides, and a phospholipase, which catalyzes production of lysophosphatidic acid (LPA) in extracellular fluids. LPA evokes growth factor-like responses including stimulation of cell proliferation and chemotaxis. This gene product stimulates the motility of tumor cells and has angiogenic properties, and its expression is upregulated in several kinds of carcinomas. The gene product is secreted and further processed to make the biologically active form. Several alternatively spliced transcript variants encoding different isoforms have been identified. [provided by RefSeq, Aug 2008]

Expression: Broad expression in placenta (RPKM 83.1), brain (RPKM 52.1) and 18 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/5168#gene-expression

PDB ID: Q13822

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index?uniprot_accession:(Q13822)

MF term ID: GO:0047391

MF term name: alkylglycerophosphoethanolamine phosphodiesterase activity