Basic information
Biomarker: IRAK1
Biomarker subtype: gene
Clinical application: treatment(theranostic target)
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Beijing
Cohort age: 59;27-71
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 178 | EC | 89 | adjacent non-tumorous tissue | 89 |
Sample information
Clinical method: qRT-PCR/western blot/Immunohistochemistry
Expression pattern : overexpression
Expression elevation: The specimens were graded into IRAK1-high-expression group (>20% of tumor cells showed positive stain) and IRAK1-low-expression group (< 20% of the tumor cells showed positive stain).
Validation in cell line : Human endometrial epithelial cell lines HEC-1-A, HEC-1-B, RL95-2, AN3CA, Ishikeuva and JEC
Validation in cell method : RNA interference,Cell proliferation assay,Establishment of stable cell lines and In vivo tumorigenicity assay,Cell apoptosis,Cell cycle assay,Wound healing assay,Cell invasion assay,Western blot,
Disease information
Statictics: Median;Range
Cohort age: 59;27-71
Related information
Description: These collective data indicated that IRAK1 overexpression promotes EC tumorigenesis by activating mitotic cell cycle and cell division pathways, and IRAK1 may serve as a promising therapeutic strategy for EC.
Approved symbol: IRAK1
Approved name: interleukin 1 receptor associated kinase 1
Locus type: gene with protein product
HGNC ID: HGNC:6112
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6112
Symbol status: Approved
Alias symbols: IRAK
OMIM: 300283
Omim link: https://www.omim.org/entry/300283
NCBI name: 3654
NCBI link: https://www.ncbi.nlm.nih.gov/gene/3654
Summary: This gene encodes the interleukin-1 receptor-associated kinase 1, one of two putative serine/threonine kinases that become associated with the interleukin-1 receptor (IL1R) upon stimulation. This gene is partially responsible for IL1-induced upregulation of the transcription factor NF-kappa B. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.
Expression: Ubiquitous expression in bone marrow (RPKM 25.0), appendix (RPKM 19.5) and 25 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/3654#gene-expression
PDB ID: P51617
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P51617)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
Source description: WP|CORUM
Term ID: WP:WP3926|CORUM:1944| CORUM:1945
Term name: ApoE and miR-146 in inflammation and atherosclerosis |IRAK1-IRAK2 complex|IRAK1-IRAK3 complex
