Basic information
Biomarker: STAR
Biomarker subtype: gene
Clinical application: prognosis
Histology type: endometrial carcinoma
Stage: high grade
Cohort characteristics
Country: Slovenia
Region: Ljubljana
Study type: Comparative Study
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 47 | EC | 47 |
Sample information
Clinical method: Quantitative Real-Time PCR
Expression pattern : down-regulated
Disease information
Related information
Description: These data thus reveal the potential of STAR and AKR1B10 as prognostic biomarkers, which calls for further validation at the protein level.
Approved symbol: STAR
Approved name: steroidogenic acute regulatory protein
Locus type: gene with protein product
HGNC ID: HGNC:11359
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11359
Symbol status: Approved
Alias symbols: STARD1
Alternative gene group name: START domain containing
OMIM: 600617
Omim link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:11359
NCBI name: 6770
NCBI link: https://www.ncbi.nlm.nih.gov/gene/6770
Summary: The protein encoded by this gene plays a key role in the acute regulation of steroid hormone synthesis by enhancing the conversion of cholesterol into pregnenolone. This protein permits the cleavage of cholesterol into pregnenolone by mediating the transport of cholesterol from the outer mitochondrial membrane to the inner mitochondrial membrane. Mutations in this gene are a cause of congenital lipoid adrenal hyperplasia (CLAH), also called lipoid CAH. A pseudogene of this gene is located on chromosome 13. [provided by RefSeq, Jul 2008]
Expression: Biased expression in adrenal (RPKM 722.2), ovary (RPKM 68.2) and 1 other tissue
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/6770#gene-expression
PDB ID: P49675
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P49675)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
Source description: WP|HPA
Term ID: WP:WP4873|HPA:0020023|HPA:0020043|HPA:0020033|HPA:0020022|HPA:0020041|HPA:0020042
Term name: Peroxiredoxin 2 induced ovarian failure|adrenal gland; cells in zona fasciculata[High]|adrenal gland; cells in zona reticularis[High]|adrenal gland; cells in zona glomerulosa[High]|adrenal gland; cells in zona fasciculata[≥Medium]|adrenal gland; cells in zona reticularis[≥Low]|adrenal gland; cells in zona reticularis[≥Medium]
