Basic information
Biomarker: TET1
Biomarker subtype: gene
Clinical application: prognosis(unfavorable)
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Taipei
Study type: retrospective study
Followed up time : >14years
Protocol age: 55.13±1.62
Control age: 55.72±1.87
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 181 | EC | 86 | normal endometrium (NE) | 30 | EH without atypia | 33 | atypical hyperplasia | 32 |
Sample information
Sample type : tissue
Clinical method: RT-PCR
Expression pattern : loss of expression
Disease information
Statictics: Mean (SD)
Protocol age: 55.13±1.62
Control age: 55.72±1.87
Related information
Description: Loss of ten-eleven translocation 1 (TET1) expression as a diagnostic and prognostic biomarker of endometrial carcinoma.
Expression figure legend: TET1 expression in samples of normal endometrium (A1), EH without atypia (B1), AH (C1), G1 of EmAC (D1), G2 of EmAC (E1), G3 of EmAC (F1), SC (G1), MC (H1), and CC (I1);
Expression figure link: https://journals.plos.org/plosone/article/figure?id=10.1371/journal.pone.0259330.g001
Approved symbol: TET1
Approved name: tet methylcytosine dioxygenase 1
Locus type: gene with protein product
HGNC ID: HGNC:29484
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29484
Symbol status: Approved
Previous symbols: CXXC zinc finger 6 tet oncogene 1
Alias symbols: LCX KIAA1676 bA119F7.1
Alternative gene group name: zf-CXXC $ en-eleven translocation enzymes
Subgroup: Zinc fingers $
OMIM: 607790
Omim link: https://www.omim.org/entry/607790
NCBI name: 80312
NCBI link: https://www.ncbi.nlm.nih.gov/gene/80312
Summary: DNA methylation is an epigenetic mechanism that is important for controlling gene expression. The protein encoded by this gene is a demethylase that belongs to the TET (ten-eleven translocation) family. Members of the TET protein family play a role in the DNA methylation process and gene activation. [provided by RefSeq, Sep 2015]
Expression: Low expression observed in reference dataset
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/80312#gene-expression
PDB ID: Q8NFU7
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q8NFU7)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
Source description: REAC
Term ID: REAC:R-HSA-5221030
Term name: TET1,2,3 and TDG demethylate DNA
