Biomarker: ZNF154 CpG

Biomarker subtype: gene

Clinical application: diagnosis(identifying solid tumor DNA)

Histology type: endometrial carcinoma

Country: Rockville

Sample type : tissue

Clinical method: PCR amplified;next-generation bisulfite amplicon sequencing

Expression pattern : hypermethylation

Validation in cell line : GM12878;K562 Cell Lines

Description: Our findings suggest that hypermethylation of the ZNF154 CpG island is a relevant biomarker for identifying solid tumor DNA;may have utility as a generalizable biomarker for circulating tumor DNA.

Approved symbol: ZNF154

Approved name: zinc finger?protein?154

Locus type: gene with protein product

HGNC ID: HGNC:12939

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:12939

Symbol status: Approved

Previous symbols: zinc finger protein 154 (pHZ-92)

Alias symbols: pHZ-92

Alternative gene group name: zf-C2H2", "Cys2His2-like fold containing

Subgroup: Zinc fingers

OMIM: 604085

Omim link: https://www.omim.org/entry/604085

NCBI name: 7710

NCBI link: https://www.ncbi.nlm.nih.gov/gene/7710

Summary: This gene encodes a protein that belongs to the zinc finger Kruppel family of transcriptional regulators, whose members are thought to function in normal and abnormal cell growth and differentiation. Hypermethylation of this gene is associated with the recurrence of non muscle invasive bladder cancer. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Mar 2014]

Expression: Ubiquitous expression in thyroid (RPKM 3.0), spleen (RPKM 2.6) and 24 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/7710#gene-expression

PDB ID: Q13106

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q13106)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D