Biomarker: ATAD2

Biomarker subtype: mRNA

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Country: Norway

Region: Bergen

Study type: Prospective study.

Followed up time : 5-years

Cohort age: 294;270

Protocol age: 156;125

Control age: 138;145

Sample type : tissue

Clinical method: Microarrays

Expression pattern : overexpression(index 3-9)

Expression elevation: Values were grouped either according to IHC cutoff (two equally sized patient groups) or in quartiles, where the upper quartile was defined as high expression.

Statictics: cutoff<66;cutoff>66

Cohort age: 294;270

Protocol age: 156;125

Control age: 138;145

Description: Our results support that IHC staining for ATAD2 may be a clinically applicable biomarker reflecting clinical phenotype and targetable alterations in endometrial carcinomas to be further explored in controlled clinical trials.

Survival figure legend: ATAD2 predicts poor prognosis in endometrial cancer

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695070/figure/F3/

Expression figure legend: Immunohistochemical detection of ATAD2 protein in endometrial carcinomas

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4695070/figure/F2/

Approved symbol: ATAD2

Approved name: ATPase family AAA domain containing 2

Locus type: gene with protein product

HGNC ID: HGNC:30123

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:30123

Symbol status: Approved

Alias symbols: GPR159

Alternative gene group name: "AAA ATPases (ATPases associated with diverse cellular activities)", "AAA+ ATPases", "ATPase family, AAA domain containing"||

Subgroup: |"MicroRNA host genes"|

OMIM: 611941

Omim link: https://www.omim.org/entry/611941

NCBI name: 29028

NCBI link: https://www.ncbi.nlm.nih.gov/gene/29028

Summary: A large family of ATPases has been described, whose key feature is that they share a conserved region of about 220 amino acids that contains an ATP-binding site. The proteins that belong to this family either contain one or two AAA (ATPases Associated with diverse cellular Activities) domains. AAA family proteins often perform chaperone-like functions that assist in the assembly, operation, or disassembly of protein complexes. The protein encoded by this gene contains two AAA domains, as well as a bromodomain. [provided by RefSeq, Jul 2008]

Expression: Broad expression in testis (RPKM 15.3), bone marrow (RPKM 13.1) and 23 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/29028#gene-expression

PDB ID: Q6PL18

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q6PL18)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D