Basic information
Biomarker: Rictor
Biomarker subtype: mRNA
Clinical application: prognosis(unfavorable)
Histology type: endometrial carcinoma
Cohort characteristics
Country: China
Region: Shangha
Followed up time : maximum follow up time> 50 months
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 47 | EC | 30 | normal endometrial tissue | 17 |
Sample information
Sample type : tissue
Clinical method: real-time quantitative RT-PCR
Expression pattern : expression
Disease information
Related information
Description: Rictor is an independent prognostic factor for endometrial carcinoma.
Survival figure legend: Univariate analyses of factors were associated with OS in test and validation cohorts by Kaplan-Meier method and log-rank test$ Prognostic significance of Rictor expression was assessed for all 249 samples separated according to pathological type, grade, vascular invasion and lymphatic metastasis by Kaplan-Meier method and log-rank test.
Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069916/figure/fig02/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069916/figure/fig03/
Expression figure legend: Rictor mRNA expression in 30 fresh EC tissue samples and 17 fresh normal endometrial tissues using real-time quantitative RT-
Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4069916/figure/fig01/
Approved symbol: RICTOR
Approved name: RPTOR independent companion of MTOR complex 2
Locus type: gene with protein product
HGNC ID: HGNC:28611
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:28611
Symbol status: Approved
Alias symbols: MGC39830 AVO3 PIA KIAA1999
Alternative gene group name: | ARM-like", "Armadillo-like helical superfamily
OMIM: 609022
Omim link: https://www.omim.org/entry/609022
NCBI name: 253260
NCBI link: https://www.ncbi.nlm.nih.gov/gene/253260
Summary: RICTOR and MTOR (FRAP1; MIM 601231) are components of a protein complex that integrates nutrient- and growth factor-derived signals to regulate cell growth (Sarbassov et al., 2004 [PubMed 15268862]).[supplied by OMIM, Mar 2008]
Expression: Ubiquitous expression in bone marrow (RPKM 9.8), testis (RPKM 7.0) and 25 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/253260#gene-expression
PDB ID: Q6R327
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q6R327)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
