Biomarker: CYP1A1

Biomarker subtype: mRNA

Clinical application: treatment(chemotherapeutic targets)

Histology type: endometrial carcinoma

Country: Greece

Region: Athens

Cohort age: 63.7;46–72

Sample type : tissue

Clinical method: qRT-PCR/Western blotting,enzyme activity assays,HPLC and mass spectrometry analysis

Expression pattern : overexpression

Statictics: Mean ;Range

Cohort age: 63.7;46–72

Description: Overexpression of active CYP1 enzymes in 21 % of the tumors highlights the potential use of the latter enzymes as chemotherapeutic targets in endometrial cancer.

Approved symbol: CYP1A1

Approved name: cytochrome P450 family 1 subfamily A member 1

Locus type: gene with protein product

HGNC ID: HGNC:2595

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2595

Symbol status: Approved

Previous symbols: CYP1

Alias symbols: cytochrome P450, subfamily I (aromatic compound-inducible), polypeptide 1 cytochrome P450, family 1, subfamily A, polypeptide 1

Subgroup: Cytochrome P450s (CYP)

OMIM: 108330

Omim link: https://www.omim.org/entry/108330

NCBI name: 1543

NCBI link: https://www.ncbi.nlm.nih.gov/gene/1543

Summary: This gene, CYP1A1, encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. The gene has been associated with lung cancer risk. A related family member, CYP1A2, is located approximately 25 kb away from CYP1A1 on chromosome 15. Alternative splicing results in multiple transcript variants encoding distinct isoforms. [provided by RefSeq, Jan 2016]

Expression: Biased expression in urinary bladder (RPKM 40.8), liver (RPKM 18.0) and 1 other tissue

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/1543#gene-expression

PDB ID: P04798

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P04798)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

MF term ID: GO:0016711

MF term name: flavonoid 3'-monooxygenase activity

BP term ID: GO:0019341 | GO:0009692 | GO:0017143

BP term name: dibenzo-p-dioxin catabolic process| ethylene metabolic process | insecticide metabolic process

Source description: REAC

Term ID: REAC:R-HSA-9018681

Term name: Biosynthesis of protectins