Biomarker: CYP1B1

Biomarker subtype: mRNA

Clinical application: treatment(chemotherapeutic targets)

Histology type: endometrial carcinoma

Country: Greece

Region: Athens

Cohort age: 63.7;46–72

Sample type : tissue

Clinical method: qRT-PCR/Western blotting,enzyme activity assays,HPLC and mass spectrometry analysis

Expression pattern : overexpression

Statictics: Mean ;Range

Cohort age: 63.7;46–72

Description: Overexpression of active CYP1 enzymes in 21 % of the tumors highlights the potential use of the latter enzymes as chemotherapeutic targets in endometrial cancer.

Approved symbol: CYP1B1

Approved name: cytochrome P450 family 1 subfamily B member 1

Locus type: gene with protein product

HGNC ID: HGNC:2597

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:2597

Symbol status: Approved

Previous symbols: GLC3A

Alias symbols: cytochrome P450, subfamily I (dioxin-inducible), polypeptide 1 (glaucoma 3, primary infantile) cytochrome P450, family 1, subfamily B, polypeptide 1

Subgroup: Cytochrome P450s (CYP)

OMIM: 601771

Omim link: https://www.omim.org/entry/601771

NCBI name: 1545

NCBI link: https://www.ncbi.nlm.nih.gov/gene/1545

Summary: This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The enzyme encoded by this gene localizes to the endoplasmic reticulum and metabolizes procarcinogens such as polycyclic aromatic hydrocarbons and 17beta-estradiol. Mutations in this gene have been associated with primary congenital glaucoma; therefore it is thought that the enzyme also metabolizes a signaling molecule involved in eye development, possibly a steroid. [provided by RefSeq, Jul 2008]

Expression: Broad expression in prostate (RPKM 32.6), endometrium (RPKM 26.2) and 19 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/1545#gene-expression

PDB ID: Q16678

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(Q16678)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

Source description: REAC | WP | HP

Term ID: REAC:R-HSA-5579000 |WP:WP2542 | HP:0008041

Term name: Defective CYP1B1 causes Glaucoma |Sulindac metabolic pathway | Late onset congenital glaucoma