Basic information
Biomarker: S100A4
Biomarker subtype: mRNA
Clinical application: prognosis(unfavorable)
Histology type: endometrial carcinoma
Cohort characteristics
Country: Korea
Region: Pusan
Followed up time : 43 months (range, 0.25-131 months).
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 135 | EC | 135 |
Sample information
Sample type : tissue
Clinical method: qRT-PCR
Expression pattern : cytoplasmic expression
Disease information
Related information
Description: In conclusion, our results indicate that S100A4 may be a biological marker indicating the recurrence and poor prognosis in patients with EC.
Approved symbol: S100A4
Approved name: S100 calcium binding protein A4
Locus type: gene with protein product
HGNC ID: HGNC:10494
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:10494
Symbol status: Approved
Previous symbols: MTS1 CAPL
Alias symbols: P9KA 18A2 PEL98 42A FSP1
Alternative gene group name: Epidermal differentiation complex|EF hand domain containing
OMIM: 114210
Omim link: https://www.omim.org/entry/114210
NCBI name: 6275
NCBI link: https://www.ncbi.nlm.nih.gov/gene/6275
Summary: The protein encoded by this gene is a member of the S100 family of proteins containing 2 EF-hand calcium-binding motifs. S100 proteins are localized in the cytoplasm and/or nucleus of a wide range of cells, and involved in the regulation of a number of cellular processes such as cell cycle progression and differentiation. S100 genes include at least 13 members which are located as a cluster on chromosome 1q21. This protein may function in motility, invasion, and tubulin polymerization. Chromosomal rearrangements and altered expression of this gene have been implicated in tumor metastasis. Multiple alternatively spliced variants, encoding the same protein, have been identified. [provided by RefSeq, Jul 2008]
Expression: Broad expression in lung (RPKM 268.4), bone marrow (RPKM 235.9) and 21 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/6275#gene-expression
PDB ID: P26447
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P26447)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
