Basic information

Biomarker: ITGB1

Biomarker subtype: mRNA

Clinical application: diagnosis

Histology type: endometrial carcinoma

Stage: low grade

Cohort characteristics

Country: Poland

Total number	Group I	Group I number	Group II	Group II number	Group III	Group III number	Group IV	Group IV number
83	EC	83

Sample information

Sample type : tissue

Clinical method: RT-PCR

Expression pattern : expression

Disease information

Description: ITGB1 mRNA expression seems to be an important marker of cancer progression and metastases in endometrial malignant tumors.

Approved symbol: ITGB1

Approved name: integrin subunit beta 1

Locus type: gene with protein product

HGNC ID: HGNC:6153

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:6153

Symbol status: Approved

Previous symbols: FNRB MSK12 MDF2

Alias symbols: CD29 GPIIA

Alternative gene group name: | cluster of differentiation molecules", "cluster of designation molecule

Subgroup: Integrins (ITG)|

OMIM: 135630

Omim link: https://www.omim.org/entry/135630

NCBI name: 3688

NCBI link: https://www.ncbi.nlm.nih.gov/gene/3688

Summary: Integrins are heterodimeric proteins made up of alpha and beta subunits. At least 18 alpha and 8 beta subunits have been described in mammals. Integrin family members are membrane receptors involved in cell adhesion and recognition in a variety of processes including embryogenesis, hemostasis, tissue repair, immune response and metastatic diffusion of tumor cells. This gene encodes a beta subunit. Multiple alternatively spliced transcript variants which encode different protein isoforms have been found for this gene. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in fat (RPKM 292.8), gall bladder (RPKM 214.5) and 25 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/3688#gene-expression

PDB ID: P05556

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P05556)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

BP term ID: GO:0051943| GO:0051951| GO:0150103

BP term name: positive regulation of amino acid uptake involved in synaptic transmission|positive regulation of glutamate uptake involved in transmission of nerve impulse| reactive gliosis

CC term ID: GO:0034677|GO:0034665|GO:0034667|GO:0034674|GO:0034678|GO:0034680|GO:0034681|GO:0034666|GO:0034668

CC term name: integrin alpha7-beta1 complex|integrin alpha1-beta1 complex|integrin alpha3-beta1 complex|integrin alpha5-beta1 complex|integrin alpha8-beta1 complex|integrin alpha8-beta1 complex|integrin alpha10-beta1 complex|integrin alpha11-beta1 complex|integrin alpha2-beta1 complex||integrin alpha4-beta1 complex

Source description: REAC|CORUM

Basic information

Cohort characteristics

Sample information

Disease information

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