Biomarker: survivin

Biomarker subtype: gene

Clinical application: treatment(therapeutic implications)

Histology type: endometrial carcinoma

Country: Iran

Region: Tehran

Sample type : tissue

Clinical method: polymerase chain reaction (PCR) restriction fragment length polymorphism (RFLP)

Expression pattern : allele C

Description: Our data are in keeping with a previous finding regarding the role of survivin gene polymorphism in malignancies. This finding highlights the role of survivin in pathogenesis of various carcinomas;which might have therapeutic implications.

Approved symbol: BIRC5

Approved name: baculoviral IAP repeat containing 5

Locus type: gene with protein product

HGNC ID: HGNC:593

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:593

Symbol status: Approved

Previous symbols: API4

Alias symbols: EPR-1 survivin

Alternative gene group name: inhibitor of apoptosis domain containing", "IAP repeat containing", "Baculovirus inhibitor of apoptosis protein repeat containing"$"CPC"

OMIM: 603352

Omim link: https://www.omim.org/entry/603352

NCBI name: 332

NCBI link: https://www.ncbi.nlm.nih.gov/gene/332

Summary: This gene is a member of the inhibitor of apoptosis (IAP) gene family, which encode negative regulatory proteins that prevent apoptotic cell death. IAP family members usually contain multiple baculovirus IAP repeat (BIR) domains, but this gene encodes proteins with only a single BIR domain. The encoded proteins also lack a C-terminus RING finger domain. Gene expression is high during fetal development and in most tumors, yet low in adult tissues. Alternatively spliced transcript variants encoding distinct isoforms have been found for this gene. [provided by RefSeq, Jun 2011]

Expression: Biased expression in bone marrow (RPKM 13.2), testis (RPKM 10.8) and 12 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/332#gene-expression

PDB ID: O15392

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(O15392)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

CC term ID: GO:1990713

CC term name: survivin complex

Source description: CORUM

Term ID: CORUM:2580$CORUM:1117

Term name: Survivin homodimer complex$CRM1-Survivin mitotic complex