Basic information
Biomarker: HE4
Biomarker subtype: gene
Clinical application: prognosis(unfavorable)
Histology type: endometrial carcinoma
Stage: high risk
Cohort characteristics
Country: Italy
Region: Brescia
Followed up time : median follow-up, 33.1 months, range 0.9–74.4 months
Cohort age: 60;78
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 66 | EC | 46 | NE | 20 |
Sample information
Sample type : serum
Clinical method: real-time PCR
Expression pattern : expression
Disease information
Statictics: cutoff<65;cutoff>65
Cohort age: 60;78
Related information
Description: Protein and HE4 gene were significantly upregulated in EC tissues and sera, compared with controls. High sHE4 levels were significantly associated with worse EC clinical characteristics
Survival figure legend: Survival curve of the FIGO I endometrioid endometrial cancer patients
Survival curve link: https://www.nature.com/articles/modpathol201175/figures/1
Expression figure legend: Favorable combination of biomarkers p21.$ Unfavorable combination of biomarkers p21, survivin and microsatellite instability.
Expression figure link: https://www.nature.com/articles/modpathol201175/figures/2 $https://www.nature.com/articles/modpathol201175/figures/3
Approved symbol: WFDC2
Approved name: WAP four-disulfide core domain 2
Locus type: gene with protein product
HGNC ID: HGNC:15939
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:15939
Symbol status: Approved
Alias symbols: HE4 WAP5 dJ461P17.6 EDDM4
OMIM: 617548
Omim link: https://www.omim.org/entry/617548
NCBI name: 10406
NCBI link: https://www.ncbi.nlm.nih.gov/gene/10406
Summary: This gene encodes a protein that is a member of the WFDC domain family. The WFDC domain, or WAP Signature motif, contains eight cysteines forming four disulfide bonds at the core of the protein, and functions as a protease inhibitor in many family members. This gene is expressed in pulmonary epithelial cells, and was also found to be expressed in some ovarian cancers. The encoded protein is a small secretory protein, which may be involved in sperm maturation. [provided by RefSeq, Jul 2008]
Expression: Biased expression in salivary gland (RPKM 317.9), endometrium (RPKM 117.3) and 8 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/10406#gene-expression
PDB ID: Q14508
PDB link: https://alphafold.ebi.ac.uk/entry/Q14508
