Biomarker: CDH1

Biomarker subtype: gene

Clinical application: prognosis

Histology type: endometrial carcinoma

Country: China

Region: Tianjin

Study type: retrospective study

Followed up time : five years

Sample type : tissue

Clinical method: immunohistochemistry/Methylation-specific PCR (MSP)

Expression pattern : CDH1 promoter hypermethylation

Expression elevation: The results of the MSP were scored when there was a clearly visible band on the gel with the methylated and unmethylated primers.

Description: We found that the hypermethylation of CDH1 promoter, which caused low expression of E-cadherin in endometrial cancer, was associated with not only clinicopathological progress of endometrial cancer but also with the overall 5-year clinical survival rate. The findings provide the potential prognostic target molecule for patients with endomethrial cancer.

Survival figure legend: Kaplan–Meier survival curves for EC patients according to sHE4 levels on the entire patient cohort

Survival curve link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101927/figure/fig4/

Expression figure legend: Representative immunohistochemical staining for HE4

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3101927/figure/fig2/

Approved symbol: CDH1

Approved name: cadherin 1

Locus type: gene with protein product

HGNC ID: HGNC:1748

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:1748

Symbol status: Approved

Previous symbols: cadherin 1, type 1, E-cadherin (epithelial)

Alias symbols: uvomorulin CD324

Alternative gene group name: | cluster of differentiation molecules", "cluster of designation molecules

Subgroup: Major cadherins (CDH) |

OMIM: 192090

Omim link: https://www.omim.org/entry/192090

NCBI name: 999

NCBI link: https://www.ncbi.nlm.nih.gov/gene/999

Summary: This gene encodes a classical cadherin of the cadherin superfamily. Alternative splicing results in multiple transcript variants, at least one of which encodes a preproprotein that is proteolytically processed to generate the mature glycoprotein. This calcium-dependent cell-cell adhesion protein is comprised of five extracellular cadherin repeats, a transmembrane region and a highly conserved cytoplasmic tail. Mutations in this gene are correlated with gastric, breast, colorectal, thyroid and ovarian cancer. Loss of function of this gene is thought to contribute to cancer progression by increasing proliferation, invasion, and/or metastasis. The ectodomain of this protein mediates bacterial adhesion to mammalian cells and the cytoplasmic domain is required for internalization. This gene is present in a gene cluster with other members of the cadherin family on chromosome 16. [provided by RefSeq, Nov 2015]

Expression: Broad expression in thyroid (RPKM 81.8), colon (RPKM 70.0) and 17 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/999#gene-expression

PDB ID: P12830

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P12830)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D

Source description: CORUM

Term ID: CORUM:5281| CORUM:5319| CORUM:5320

Term name: Cell-cell junction complex (CDH1-CTNNB1) | CDH1-CKS1B complex | CDH1-SKP2 complex