Biomarker: ephrinB2

Biomarker subtype: mRNA

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Country: Japan

Region: Gifu City

Followed up time : 60-month

Sample type : tissue

Clinical method: real-time RT-PCR

Expression pattern : Overexpression

Description: EphrinB2 and EphB4 were overexpressed during the tumor advancement as dedifferentiation and myometrial invasion. Therefore, ephrinB2/EphB4 might work on tumor advancement and may be recognized as a novel prognostic indicator for uterine endometrial cancers.

Approved symbol: EFNB2

Approved name: ephrin B2

Locus type: gene with protein product

HGNC ID: HGNC:3227

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3227

Symbol status: Approved

Previous symbols: EPLG5

Alias symbols: LERK5 Htk-L HTKL MGC126226 MGC126227 MGC126228

Alternative gene group name: "Eph family receptor interacting proteins", "Ephrin ligands"

Subgroup: Receptor ligands

OMIM: 600527

Omim link: https://www.omim.org/entry/600527

NCBI name: 1948

NCBI link: https://www.ncbi.nlm.nih.gov/gene/1948

Summary: This gene encodes a member of the ephrin (EPH) family. The ephrins and EPH-related receptors comprise the largest subfamily of receptor protein-tyrosine kinases and have been implicated in mediating developmental events, especially in the nervous system and in erythropoiesis. Based on their structures and sequence relationships, ephrins are divided into the ephrin-A (EFNA) class, which are anchored to the membrane by a glycosylphosphatidylinositol linkage, and the ephrin-B (EFNB) class, which are transmembrane proteins. This gene encodes an EFNB class ephrin which binds to the EPHB4 and EPHA3 receptors. [provided by RefSeq, Jul 2008]

Expression: Ubiquitous expression in lung (RPKM 8.5), colon (RPKM 7.4) and 23 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/1948#gene-expression

PDB ID: P52799

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P52799)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D