Biomarker: ERRgamma

Biomarker subtype: mRNA

Clinical application: prognosis

Histology type: endometrioid endometrial carcinoma

Country: China

Region: Beijing

Study type: Comparative Study

Sample type : tissue

Clinical method: RT-PCR/immunohistochemistry

Expression pattern : expression;amplification

Expression elevation: Immunoreactivities of ERRs were classified into four groups: 2, ,10% of positive cells; 1, 10–25% of positive cells; 11, 25–50% of positive cells; and 111, .50% of positive cells.

Description: Results suggested that might participate in the tumorigenesis of endometrial adenocarcinoma. ERRgamma are promising to be new prognostic factors in endometrial adenocarcinoma.

Approved symbol: ESRRG

Approved name: estrogen related receptor gamma

Locus type: gene with protein product

HGNC ID: HGNC:3474

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:3474

Symbol status: Approved

Alias symbols: NR3B3 ERRg ERR-gamma

Alternative gene group name: Nuclear receptor subfamily 3 group B

Subgroup: Nuclear hormone receptors (NR)

OMIM: 602969

Omim link: https://www.omim.org/entry/602969

NCBI name: 2104

NCBI link: https://www.ncbi.nlm.nih.gov/gene/2104

Summary: This gene encodes a member of the estrogen receptor-related receptor (ESRR) family, which belongs to the nuclear hormone receptor superfamily. All members of the ESRR family share an almost identical DNA binding domain, which is composed of two C4-type zinc finger motifs. The ESRR members are orphan nuclear receptors; they bind to the estrogen response element and steroidogenic factor 1 response element, and activate genes controlled by both response elements in the absence of any ligands. The ESRR family is closely related to the estrogen receptor (ER) family. They share target genes, co-regulators and promoters, and by targeting the same set of genes, the ESRRs seem to interfere with the ER-mediated estrogen response in various ways. It has been reported that the family member encoded by this gene functions as a transcriptional activator of DNA cytosine-5-methyltransferases 1 (Dnmt1) expression by direct binding to its response elements in the DNMT1 promoters, modulates cell proliferation and estrogen signaling in breast cancer, and negatively regulates bone morphogenetic protein 2-induced osteoblast differentiation and bone formation. Multiple alternatively spliced transcript variants have been identified, which mainly differ at the 5' end and some of which encode protein isoforms differing in the N-terminal region. [provided by RefSeq, Aug 2011]

Expression: Biased expression in kidney (RPKM 4.4), stomach (RPKM 3.1) and 12 other tissues

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/2104#gene-expression

PDB ID: P62508

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index?uniprot_accession:(P62508)

Source description: TF

Term ID: TF:M06468

Term name: Factor: ZNF808; motif: KGGGACTGCATA