Basic information
Biomarker: Haymaker
Biomarker subtype: gene
Clinical application: diagnosis
Histology type: endometrial carcinoma
Cohort characteristics
Country: USA
Region: New York
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 85 | EC | 23 | ovarian carcinoma | 10 | cervical carcinomas | 12 | benign gynecologic tissue specimens | 36 |
Sample information
Sample type : tissue
Clinical method: RT-PCR/immunohistochemistry
Expression pattern : positive expression
Expression elevation: The categories 0%, 1–5%, 6–25%, 26– 50%, 51–75%, and .75% were used to characterize the proportion of cells that expressed the Haymaker antigen. For those specimens that expressed Haymaker, the intensity of staining was graded on a 11, 12, or 13 scale.
Disease information
Related information
Description: The expression of Haymaker protein does not appear, therefore, to be a marker of malignant transformation of the epithelium of gynecologic organs but rather distinguishes both normal and malignant epithelial cells from normal connective tissue and smooth muscle cells.
Approved symbol: TOMM40
Approved name: translocase of outer mitochondrial membrane 40
Locus type: gene with protein product
HGNC ID: HGNC:18001
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:18001
Symbol status: Approved
Alias symbols: PEREC1 D19S1177E C19orf1 TOM40 PER-EC1
Alternative gene group name: TOM complex
OMIM: 608061
Omim link: https://www.omim.org/entry/608061
NCBI name: 10452
NCBI link: https://www.ncbi.nlm.nih.gov/gene/10452
Summary: The protein encoded by this gene is localized in the outer membrane of the mitochondria. It is the channel-forming subunit of the translocase of the mitochondrial outer membrane (TOM) complex that is essential for import of protein precursors into mitochondria. Alternatively spliced transcript variants have been found for this gene. [provided by RefSeq, Aug 2015]
Expression: Ubiquitous expression in colon (RPKM 13.7), esophagus (RPKM 12.2) and 25 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/10452#gene-expression
PDB ID: O96008
PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(O96008)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D
Source description: MIRNA$CORUM
Term ID: MIRNA:hsa-miR-3610$MIRNA:hsa-miR-1306-3p$CORUM:3092
Term name: hsa-miR-3610$hsa-miR-1306-3p$APP-TOM40 complex
