Basic information
Biomarker: EIG121
Biomarker subtype: gene
Clinical application: prognosis(hyperestrogenic state and estrogen-related)
Histology type: endometrioid endometrial carcinoma
Cohort characteristics
Country: USA
Region: Texas
Study type: Randomized Controlled Trial
| Total number | Group I | Group I number | Group II | Group II number | Group III | Group III number | Group IV | Group IV number |
|---|---|---|---|---|---|---|---|---|
| 172 | healthy postmenopausal | 30 | endometrial cancers | 118 | endometrial samples | 24 |
Sample information
Sample type : tissue
Clinical method: cDNA microarray screen/RT-PCR/Immunohistochemistry
Expression pattern : expression
Disease information
Related information
Description: Our results suggest that EIG121 is a good endometrial biomarker associated with a hyperestrogenic state and estrogen-related type I endometrial adenocarcinoma.
Approved symbol: ELAPOR1
Approved name: endosome-lysosome associated apoptosis and autophagy regulator 1
Locus type: gene with protein product
HGNC ID: HGNC:29618
HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:29618
Symbol status: Approved
Previous symbols: KIAA1324
Alias symbols: maba1 EIG121
OMIM: 611298
Omim link: https://www.omim.org/entry/611298
NCBI name: 57535
NCBI link: https://www.ncbi.nlm.nih.gov/gene/57535
Summary: Expression of this gene is induced by estrogen and the encoded protein has been characterized as a transmembrane protein. The encoded protein has been found in to correlate with survival in certain carcinomas (PMID: 21102415) and may be important for cellular response to stress (PMID: 21072319). Alternative splicing results in multiple transcript variants. [provided by RefSeq, May 2012]
Expression: Biased expression in stomach (RPKM 32.4), salivary gland (RPKM 26.9) and 13 other tissues
NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/57535#gene-expression
PDB ID: Q6UXG2
PDB link: https://alphafold.ebi.ac.uk/entry/Q6UXG2
