Biomarker: PR

Biomarker subtype: gene

Clinical application: prognosis(unfavorable)

Histology type: endometrial carcinoma

Stage: stage I

Country: Dutch

Region: Maastricht

Followed up time : 32 (9–141)/45.5 (34–120)

Protocol age: 70.5;51–83

Control age: 69.5;54–93

Sample type : tissue

Clinical method: PCR-RFLP/immunohistochemistry

Expression pattern : Low Expression and carrying the PROGINS allele

Expression elevation: The percentage of stained tumour cells (0%, 0–10%, 10–50%, >50%) and the intensity of staining (absent, weak, moderate, or strong) were determined (0, 1, 2, or 3 for each variable) for the entire tumour area within the section, and a staining index (SI, ranging from 0 to 9) was calculated by multiplying categorized parameters

Statictics: Mean ;Range

Protocol age: 70.5;51–83

Control age: 69.5;54–93

Description: In conclusion, low PR expression tended to be associated with recurrent disease, and PR expression in tumours from patients carrying the PROGINS allele was predictive of the risk of recurrence.

Approved symbol: PGR

Approved name: progesterone receptor

Locus type: gene with protein product

HGNC ID: HGNC:8910

HGNC link: https://www.genenames.org/data/gene-symbol-report/#!/hgnc_id/HGNC:8910

Symbol status: Approved

Alias symbols: PR NR3C3

Alternative gene group name: 3-Ketosteroid receptors

Subgroup: Nuclear hormone receptors (NR)

OMIM: 607311

Omim link: https://www.omim.org/entry/607311

NCBI name: 5241

NCBI link: https://www.ncbi.nlm.nih.gov/gene/5241

Summary: This?gene?encodes a member of the steroid receptor superfamily. The encoded?protein?mediates the physiological effects of?progesterone, which plays a central role in reproductive events associated with the establishment and maintenance of pregnancy. This?gene?uses two distinct promotors and translation start sites in the first exon to produce several transcript variants, both?protein?coding and non-protein?coding. Two of the isoforms (A and B) are identical except for an additional 165 amino acids found in the N-terminus of isoform B and mediate their own response genes and physiologic effects with little overlap. [provided by RefSeq, Sep 2015]

Expression: Biased expression in endometrium (RPKM 46.4) and ovary (RPKM 5.5)

NCBI gene expression https://www.ncbi.nlm.nih.gov/gene/5241#gene-expression

PDB ID: P06401

PDB link: https://www.ebi.ac.uk/pdbe/entry/search/index/?searchParams=%7B%22q_uniprot%22:%5B%7B%22value%22:%22(P06401)%22,%22condition1%22:%22AND%22,%22condition2%22:%22Contains%22%7D%5D,%22resultState%22:%7B%22tabIndex%22:0,%22paginationIndex%22:1,%22perPage%22:%2210%22,%22sortBy%22:%22Sort%20by%22%7D%7D