Biomarker: DNA ploidy

Biomarker subtype: DNA

Clinical application: prognosis

Histology type: endometrioid endometrial carcinoma

Stage: stage I

Country: Sweden

Region: Stockholm

Study type: Comparative Study

Followed up time : 98 months

Sample type : tissue

Clinical method: Flow cytometry

Expression pattern : diploid versus nondiploid; RR 5.1

Description: DNA ploidy is an independent prognostic indicator of overall survival in stage I endometrial endometrioid endometrial carcinoma .

Detailed Description: Ploidy is the number of complete sets of chromosomes in a cell, and hence the number of possible alleles for autosomal and pseudoautosomal genes. Sets of chromosomes refer to the number of maternal and paternal chromosome copies, respectively, in each homologous chromosome pair, which chromosomes naturally exist as. Somatic cells, tissues, and individual organisms can be described according to the number of sets of chromosomes present (the "ploidy level"): monoploid (1 set), diploid (2 sets), triploid (3 sets), tetraploid (4 sets), pentaploid (5 sets), hexaploid (6 sets), heptaploid[doi:10.1007/bf00119108] or septaploid[3] (7 sets), etc. The generic term polyploid is often used to describe cells with three or more chromosome sets.[doi:10.1007/978-3-642-96327-8][Darlington, C. D. (Cyril Dean) (1937). Recent advances in cytology. Philadelphia: P. Blakiston's son & co. p. 60.]