Biomarker: 16α-OHE1 -ERα

Histology type: endometrial carcinoma

Country: KSA

Region: Abha

Followed up time :

Subgroup 1 number: Endometrial cancer

Subgroup 2 name : Healthy controls

Subgroup 1 number: 120

Subgroup 2 number: 40

Cohort statistics: Mean (SD)

Description: 16α-OHE1 -ERα is a high-affinity antigen for EC antibodies in the serum of EC patients and might function as a biomarker for this disease.

Sample type : serum

Sample method: ELISA,quantitative precipitation titration

Expression pattern : high-affinity antigen for EC antibodies

Expression elevation: Percent inhibition was calculated using the formula: Percent inhibition = (1− Ainhibited)/Auninhibited × 100

Subgroup 1 age: 64.9 ± 9.2

Subgroup 2 age: 63.4 ± 5.2

Status: Expected but not Quantified

HMDB ID: HMDB0000313

Secondary accession numbers: HMDB00313

Common name: 16b-Hydroxyestrone

Description: 16b-Hydroxyestrone belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane. Thus, 16b-hydroxyestrone is considered to be a steroid lipid molecule. 16b-Hydroxyestrone is a very hydrophobic molecule, practically insoluble (in water), and relatively neutral.

Chemical formula: C18H22O3

Chemical taxonomy description: Belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Steroids and steroid derivatives

Chemical taxonomy sub class: Estrane steroids

Direct parent: Estrogens and derivatives

Alternative parents: 3-hydroxysteroids 17-oxosteroids 16-beta-hydroxysteroids Phenanthrenes and derivatives Tetralins 1-hydroxy-2-unsubstituted benzenoids Secondary alcohols Ketones Cyclic alcohols and derivatives Organic oxides Hydrocarbon derivatives

Substituents: Estrogen-skeleton 3-hydroxysteroid Hydroxysteroid 17-oxosteroid Oxosteroid 16-beta-hydroxysteroid 16-hydroxysteroid Phenanthrene Tetralin 1-hydroxy-2-unsubstituted benzenoid Benzenoid Cyclic alcohol Secondary alcohol Ketone Carbonyl group Organooxygen compound Alcohol Hydrocarbon derivative Organic oxide Organic oxygen compound Aromatic homopolycyclic compound

Molecular framework: Aromatic homopolycyclic compounds

Disposition: Biological location The physiological origin within an organism, including anatomical compnents, biofluids and excreta Cellular substructure Extracellular

Associated disorders diseases: None

KEGG compound ID: C05300

CPD link: https://www.genome.jp/dbget-bin/www_bget?cpd:C05300

HMDB link: https://hmdb.ca/metabolites/HMDB0000313