Biomarker: estriol (E3)

Histology type: endometrial carcinoma

Country: Canada

Region: Québec

Followed up time :

Cohort statistics: Mean (SD)

Description: Estradiol metabolites as biomarkers of endometrial cancer prognosis after surgery

Sample type : serum

Sample method: mass spectrometry-based assays,

Expression pattern : preoperative >30.5 pg/mL

Cohort age: 65.1 ± 8.9

Status: Detected and Quantified

HMDB ID: HMDB0000153

Secondary accession numbers: HMDB00153

Common name: Estriol

Description: Estriol is a metabolite of estrone metabolized via 16alpha-hydroxyestrone through the enzyme 16alpha-hydroxysteroid dehydrogenase (EC 1.1.1.147) or to 2- or 4-hydroxyestrone (catechol estrogens) by the action of catecho-O-methyltransferase (EC 2.1.1.6). The latter metabolites can be formed in the brain and may compete with receptors for catecholamines. Metabolites are conjugated with sulfate or glucuronide before excretion by the kidney. During pregnancy, estriol constitutes 60-70% of the total estrogens, increasing to 300-500-fold in relation to non-pregnant women. The late term human fetus produces relatively large amounts of 16 alphahydroxy DHEA, which serves the mother as a precursor of estriol. It has been shown that 90% of the precursors for the formation of estriol are of fetal origin. If abnormal maternal serum screening results, specifically low levels of unconjugated estriol in the second trimester are detected, a diagnosis of Smith-Lemli-Opitz syndrome (SLOS),or RSH is suspected. SLOS is an autosomal recessive disorder caused by mutations of the gene encoding 7-dehydrocholesterol reductase (EC 1.3.1.21, DHCR7). (PMID: 16202579 , 16112271 , 16097001 ).

Chemical formula: C18H24O3

Chemical taxonomy description: Belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Steroids and steroid derivatives

Chemical taxonomy sub class: Estrane steroids

Direct parent: Estrogens and derivatives

Alternative parents: 3-hydroxysteroids 17-hydroxysteroids 16-alpha-hydroxysteroids Phenanthrenes and derivatives Tetralins 1-hydroxy-2-unsubstituted benzenoids Secondary alcohols Cyclic alcohols and derivatives 1,2-diols Hydrocarbon derivatives

Substituents: Estrogen-skeleton 3-hydroxysteroid 17-hydroxysteroid 16-hydroxysteroid 16-alpha-hydroxysteroid Hydroxysteroid Phenanthrene Tetralin 1-hydroxy-2-unsubstituted benzenoid Benzenoid Cyclic alcohol Secondary alcohol 1,2-diol Polyol Organooxygen compound Hydrocarbon derivative Alcohol Organic oxygen compound Aromatic homopolycyclic compound

Molecular framework: Aromatic homopolycyclic compounds

Disposition: Biological location Cellular substructure: Cytoplasm Organelle: Endoplasmic reticulum Extracellular Non-excretory biofluid: Blood Excreta:Urine Organ substructure: Adrenal cortex Organ:Gland,Adrenal gland,Kidney,Liver, Placenta

Source Pulses,Fruits,Animal foods,Milk and milk products

Associated disorders diseases: #Pregnancy [PubMed:2994907 ] #Diabetes mellitus type 2 [PubMed:484160 ]# Aromatase deficiency[PubMed:9177373 ]

KEGG compound ID: C05141

CPD link: https://www.genome.jp/dbget-bin/www_bget?cpd:C05141

HMDB link: https://hmdb.ca/metabolites/HMDB0000153