Biomarker: 4-OHE2

Histology type: endometrial carcinoma

Country: China

Region: Hebei

Followed up time :

Subgroup 1 number: post-menopausal female endometrial cancer

Subgroup 2 name : post-menopausal healthy

Subgroup 1 number: 23

Subgroup 2 number: 23

Cohort statistics: Average

Description: The results of this study indicate an imbalance of estrogen metabolites in endometrial carcinogenesis, and that the elevation of 4-OHE2 may be used as a potential biomarker for the risk assessment of estrogen-induced endometrial cancer.

Sample type : urine

Sample method: liquid chromatography-mass spectrometry

Expression pattern : elevation

Subgroup 1 age: 45–62 years.

Subgroup 2 age: 46–67 years

Status: Expected but not Quantified

HMDB ID: HMDB0005896

Secondary accession numbers: HMDB05896

Common name: 4-Hydroxyestradiol

Description: 4-Hydroxyestradiol, also known as 3,4,17beta-estriol or 4OHE2, belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane. Thus, 4-hydroxyestradiol is considered to be a steroid. Based on a literature review a significant number of articles have been published on 4-Hydroxyestradiol.

Chemical formula: C18H24O3

Chemical taxonomy description: Belongs to the class of organic compounds known as estrogens and derivatives. These are steroids with a structure containing a 3-hydroxylated estrane.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Steroids and steroid derivatives

Chemical taxonomy sub class: Estrane steroids

Direct parent: Estrogens and derivatives

Alternative parents: 3-hydroxysteroids 17-hydroxysteroids Phenanthrenes and derivatives Tetralins 1-hydroxy-4-unsubstituted benzenoids 1-hydroxy-2-unsubstituted benzenoids Secondary alcohols Cyclic alcohols and derivatives Polyols Hydrocarbon derivatives

Substituents: Estrogen-skeleton 3-hydroxysteroid 4-hydroxysteroid 17-hydroxysteroid Hydroxysteroid Phenanthrene Tetralin 1-hydroxy-4-unsubstituted benzenoid 1-hydroxy-2-unsubstituted benzenoid Benzenoid Cyclic alcohol Secondary alcohol Polyol Organooxygen compound Organic oxygen compound Hydrocarbon derivative Alcohol Aromatic homopolycyclic compound

Molecular framework: Aromatic homopolycyclic compounds

Disposition: Biological location The physiological origin within an organism, including anatomical compnents, biofluids and excreta Cellular substructure Extracellular

Source Animal foods

Associated disorders diseases: None

KEGG compound ID: C14209

CPD link: https://www.genome.jp/dbget-bin/www_bget?cpd:C14209

HMDB link: https://hmdb.ca/metabolites/HMDB0005896