Biomarker: Cer(d18:1/18:0)

Histology type: endometrial carcinoma

Stage: early-stage EC

Country: China

Region: Jiangsu

Followed up time :

Description: In conclusion, we established a novel and non-invasive lipid biomarker for early-stage EC detection and these findings may provide new insight into the pathological mechanisms of EC.

Sample method: UHPLC-MS/MS

Status: Detected and Quantified

HMDB ID: HMDB0004950

Secondary accession numbers: HMDB0000829 HMDB00829 HMDB04950

Common name: Cer(d18:1/18:0)

Description: N-Stearoylsphingosine belongs to the group of compounds known as ceramides. Ceramides (N-acylsphingosine) are one of the hydrolysis byproducts of sphingomyelin by the enzyme sphingomyelinase (sphingomyelin phosphorylcholine phosphohydrolase E.C.3.1.4.12) which has been identified in the subcellular fractions of human epidermis (PMID 25935 ) and many other tissues. They can also be synthesized from serine and palmitate in a de novo pathway and are regarded as important cellular signals for inducing apoptosis (PMID 14998372 ). N-acylsphingosine is key in the biosynthesis of glycosphingolipids and gangliosides.

Chemical formula: C36H71NO3

Chemical taxonomy description: Belongs to the class of organic compounds known as long-chain ceramides. These are ceramides bearing a long chain fatty acid.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Sphingolipids 

Chemical taxonomy sub class: Ceramides

Direct parent: Long-chain ceramides

Alternative parents: N-acyl amines Secondary carboxylic acid amides Secondary alcohols Primary alcohols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds

Substituents: Long-chain ceramide Fatty amide N-acyl-amine Fatty acyl Carboxamide group Secondary alcohol Secondary carboxylic acid amide Carboxylic acid derivative Primary alcohol Organooxygen compound Organonitrogen compound Organic oxide Organopnictogen compound Organic oxygen compound Alcohol Organic nitrogen compound Carbonyl group Hydrocarbon derivative Aliphatic acyclic compound

Molecular framework: Aliphatic acyclic compounds

Physiological effect: Health effect Insulin resistance (PMID: 24214972) Diabetes mellitus (PMID: 17588815) Neurodegenerative disease (PMID: 17588815) Metabolic syndrome (HMDB: HMDB0004950) Lipotoxicity (HMDB: HMDB0004950) Organoleptic effect Touch Smooth (HMDB: HMDB0004950)

Disposition: Cytoplasm (HMDB: HMDB0004950) Myelin sheath (HMDB: HMDB0004950) Testicle (HMDB: HMDB0004950) Skin (HMDB: HMDB0004950) Cell membrane (HMDB: HMDB0004950) Intracellular membrane (HMDB: HMDB0004950)

KEGG compound ID: C00195

CPD link: https://www.genome.jp/dbget-bin/www_bget?cpd:C00195

HMDB link: https://hmdb.ca/metabolites/HMDB0004950

PubChem CID: 5283565

PubChem CID link: https://pubchem.ncbi.nlm.nih.gov/compound/5283565