Biomarker: SM C18:0

Histology type: endometrial carcinoma

Stage: risk

Country: ten European countries

Region: EPIC study

Study type: Observational Study

Followed up time :

Cohort statistics: Average

Description: These findings suggest that variation in levels of SM C18:0 may represent specific pathways linked to endometrial cancer development. If causal, these pathways may offer novel targets for endometrial cancer prevention.

Sample type : serum

Sample method: liquid chromatography-mass spectrometry

Subgroup 1 age: 63.0±7.9

Expression figure legend: Odds ratios (ORs) and P-values for the associations between metabolites and risk of endometrial cancer in (A) unadjusted models (B) BMI-adjusted models&Odds ratios (ORs) and P-values for the associations between metabolite ratios and risk of endometrial cancer in (A) unadjusted models (B) BMI-adjusted models.

Expression figure link: https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336647/figure/f0005/$ https://www.ncbi.nlm.nih.gov/pmc/articles/PMC8336647/figure/f0010/

Status: Detected and Quantified

HMDB ID: HMDB0001348

Secondary accession numbers: HMDB0012099 HMDB0062559 HMDB01348 HMDB12099 HMDB62559

Common name: SM(d18:1/18:0)

Description: Sphingomyelin (d18:1/18:0) or SM(d18:1/18:0) is a type of sphingolipid found in animal cell membranes, especially in the membranous myelin sheath which surrounds some nerve cell axons. It usually consists of phosphorylcholine and ceramide. SM(d18:1/18:0) consists of a sphingosine backbone and a stearic acid chain. In humans, sphingomyelin is the only membrane phospholipid not derived from glycerol. Like all sphingolipids, SM has a ceramide core (sphingosine bonded to a fatty acid via an amide linkage). In addition, it contains one polar head group, which is either phosphocholine or phosphoethanolamine. The plasma membrane of cells is highly enriched in sphingomyelin and is considered largely to be found in the exoplasmic leaflet of the cell membrane. However, there is some evidence that there may also be a sphingomyelin pool in the inner leaflet of the membrane. Moreover, neutral sphingomyelinase-2, an enzyme that breaks down sphingomyelin into ceramide, has been found to localize exclusively to the inner leaflet further suggesting that there may be sphingomyelin present there. Sphingomyelin can accumulate in a rare hereditary disease called Niemann-Pick Disease, types A and B. Niemann-Pick disease is a genetically-inherited disease caused by a deficiency in the enzyme sphingomyelinase, which causes the accumulation of sphingomyelin in spleen, liver, lungs, bone marrow, and the brain, causing irreversible neurological damage. SMs play a role in signal transduction. Sphingomyelins are synthesized by the transfer of phosphorylcholine from phosphatidylcholine to a ceramide in a reaction catalyzed by sphingomyelin synthase.

Chemical formula: C41H83N2O6P

Chemical taxonomy description: Belongs to the class of organic compounds known as phosphosphingolipids. These are sphingolipids with a structure based on a sphingoid base that is attached to a phosphate head group. They differ from phosphonospingolipids which have a phosphonate head group.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Sphingolipids

Chemical taxonomy sub class: Phosphosphingolipids

Direct parent: Phosphosphingolipids

Alternative parents: Phosphocholines Phosphoethanolamines Dialkyl phosphates N-acyl amines Tetraalkylammonium salts Secondary carboxylic acid amides Secondary alcohols Organopnictogen compounds Organic zwitterions Organic salts Organic oxides Hydrocarbon derivatives Carbonyl compounds Amines

Substituents: Sphingoid-1-phosphate or derivatives Phosphocholine Phosphoethanolamine Dialkyl phosphate Fatty amide N-acyl-amine Organic phosphoric acid derivative Phosphoric acid ester Fatty acyl Alkyl phosphate Tetraalkylammonium salt Quaternary ammonium salt Secondary carboxylic acid amide Secondary alcohol Carboxamide group Carboxylic acid derivative Organic zwitterion Alcohol Organic oxide Organooxygen compound Organonitrogen compound Organopnictogen compound Organic oxygen compound Organic nitrogen compound Hydrocarbon derivative Carbonyl group Amine Organic salt Aliphatic acyclic compound

Molecular framework: Aliphatic acyclic compounds

Physiological effect: Genetic disorder Inborn errors of metabolism:Fabry disease,Krabbe disease Metabolic disorder: Obesity (PMID: 4434100 , PMID: 1481808 , PMID: 2044610 , +66 More ) Digestive system disorder:Gastrointestinal disorder,Upper GI Disorder,Eosinophilic esophagitis (PMID: 17334708 , PMID: 32966057 , PMID: 22623390 , +128 More )

Disposition: Biological location Organ:Placenta,Brain,Liver,Spleen Cellular substructure:Extracellular Non-excretory biofluid:Blood,Breast milk,Saliva Excreta:Feces,Urine Cell:Hematocyte,Erythrocyte

Source Animal foods, Milk and milk products

Associated disorders diseases: #Obesity #Colorectal cancer [PubMed:25037050 ] #Eosinophilic esophagitis

KEGG compound ID: Not Available

CPD link: Not Available

Process: Sphingolipid metabolism

HMDB link: https://hmdb.ca/metabolites/HMDB0001348