Biomarker: C16-ceramide

Histology type: endometrioid endometrial carcinoma

Country: Slovenia

Region: Maribor

Study type: prospective study

Followed up time :

Subgroup 1 number: endometrial cancer

Subgroup 2 name : no malignancie

Subgroup 1 number: 15

Subgroup 2 number: 21

Cohort statistics: Mean (SD)

Description: C16-ceramide identified as potential diagnostic biomarkers for EC. Additionally, these identified metabolites may provide additional insight into cancer cell metabolism.

Sample type : serum

Sample method: HPLC-TQ/MS

Subgroup 1 age: 64±14

Subgroup 2 age: 54±19

Expression figure legend: ROC curves and boxplot representations for 4 top performing biomarkers as analyzed by univariate analysis.

Expression figure link: https://ars.els-cdn.com/content/image/1-s2.0-S1896112620300456-gr4_lrg.jpg

Status: Detected and Quantified

HMDB ID: HMDB0249508

Common name: C16-Ceramide

Description: N-Palmitoylsphingosine belongs to the class of organic compounds known as ceramides. These are lipid molecules containing a sphingosine in which the amine group is linked to a fatty acid. Based on a literature review a significant number of articles have been published on N-Palmitoylsphingosine. This compound has been identified in human blood as reported by (PMID: 31557052 ). C16-ceramide is not a naturally occurring metabolite and is only found in those individuals exposed to this compound or its derivatives. Technically C16-Ceramide is part of the human exposome. The exposome can be defined as the collection of all the exposures of an individual in a lifetime and how those exposures relate to health. An individual's exposure begins before birth and includes insults from environmental and occupational sources.

Chemical formula: C34H67NO3

Chemical taxonomy description: Belongs to the class of organic compounds known as ceramides. These are lipid molecules containing a sphingosine in which the amine group is linked to a fatty acid.

Chemical taxonomy kingdom: Organic compounds

Chemical taxonomy super class: Lipids and lipid-like molecules

Chemical taxonomy class: Sphingolipids

Chemical taxonomy sub class: Ceramides

Direct parent: Ceramides

Alternative parents: N-acyl amines Secondary carboxylic acid amides Secondary alcohols Primary alcohols Organopnictogen compounds Organonitrogen compounds Organic oxides Hydrocarbon derivatives Carbonyl compounds

Substituents: Ceramide Fatty amide N-acyl-amine Fatty acyl Carboxamide group Secondary alcohol Secondary carboxylic acid amide Carboxylic acid derivative Primary alcohol Organooxygen compound Organonitrogen compound Organic oxide Organopnictogen compound Organic oxygen compound Alcohol Organic nitrogen compound Carbonyl group Hydrocarbon derivative Aliphatic acyclic compound

Molecular framework: Aliphatic acyclic compounds

Associated disorders diseases: None

KEGG compound ID: Not Available

CPD link: Not Available

HMDB link: https://hmdb.ca/metabolites/HMDB0249508